Main Cast:
Guy Henry as Henrik Hanssen – Consultant General Surgeon/ CEO
Hugh Quarshie as Ric Griffin – Consultant General Surgeon
Rosie Marcel as Jac Naylor – Consultant Cardiothoracic Surgeon/ Darwin Clinical Lead
Paul McGann as John Gaskell - Consultant Neurosurgeon/ Professor
Bob Barrett as Sacha Levy – Consultant General Surgery
Hermione Gulliford as Roxanna MacMillan - Consultant Neurosurgeon
David Ames as Dominic Copeland – CT1 General Surgery/ Registrar General Surgeon
Belinda Owusu as Nicky McKendrick - F1 Doctor
Salma Hoque as Meena Chowdhury - F1 Doctor
Alex Walkinshaw as Adrian 'Fletch' Fletcher – Director of Nursing
Kaye Wragg as Estelle Di Lucca – Staff Nurse
Lee Mead as Ben "Lofty" Chiltern - Staff Nurse
Jaye Jacobs as Donna Jackson - Staff Nurse/ Senior Staff Nurse
Cast Changes:
Returning:
Catherine Russell as Serena Campbell – Consultant General Surgeon/ Acting CEO (from episode 6)
Jemma Redgrave as Bernie Wolfe - Consultant General Surgeon (TBC)
Departing:
James Anderson as Oliver Valentine – Cardiothoracic Registrar (until episode 13)
Joining:
Marcus Griffiths as Xavier 'Zav' Duval - Registrar General Surgeon (from episode 8)
Guest Cast:
Jules Robertson as Jason Haynes - Porter
Camilla Arfwedson as Zosia March (1 episode)
Olivia Poulet as Abigail Tait - CEO (from episode 14)
Casualty Crossovers:
Unknown
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