Main Cast:
Amanda Mealing as Connie Beauchamp - Consultant/ Clinical Lead
Jaye Griffiths as Elle Gardner - Consultant
William Beck as Dylan Keogh - Consultant
George Rainsford as Ethan Hardy - Specialist Registrar/ Consultant/ Acting Clinical Lead
Chelsea Halfpenny as Alicia Munroe - F2/ Specialist Registrar
Derek Thompson as Charlie Fairhead - Senior Charge Nurse
Cathy Shipton as Lisa "Duffy" Duffin - Ward Sister/ Midwife
Charles Venn as Jacob Masters - Clinical Nurse Manager
Amanda Henderson as Robyn Miller - Staff Nurse
Azuka Oforka as Louise Tyler - Staff Nurse
Jason Durr as David Hide - Staff Nurse
Michael Stevenson as Iain Dean - Paramedic
Tony Marshall as Noel Garcia - Receptionist
Joining Cast:
Charlotte Salt as Sam Nicholls - Paramedic (from episode 5)
Neet Mohan as Rashid Masum - F1 (from episode 11)
Michelle Fox as Bea Kinsella - F1 (from episode 22)
Di Botcher as Jan Jennings - Operational Duty Manager (from episode 35)
Maddy Hill as TBA - Paramedic (Summer 2018)
Exiting Cast:
Lloyd Everitt as Jez Andrews - Paramedic (until episode 2)
Crystal Yu as Lily Chao - Specialist Registrar (until episode 11)
Jamie Davis as Max Walker - Porter (until episode 19)
Guest Cast:
Ian Bleasdale as Josh Griffiths (episodes 5, 6)
Sharon Gless as Zsa Zsa Harper-Jenkinson (episode 13)
Sunetra Sarker as Zoe Hanna (episode 19)
Holby City Crossovers:
Rosie Marcel as Jac Naylor (episode 24, 27)
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